Okay, say I wanted a beef-ier (Is that even a word?) Case, Like a giant tube with a brain in it, or a dieing human being kept alive, (sometimes it just looks like the brains are too fragile and unimportant, why keep the most powerful beings on the planet in a pickle Jar?) could I just edt the sprite? Would their be anything else I'd have to edit in the .ini files? If I just wanted a better looking brain could I just edit the sprite and the basic, renameing of the filepaths in the .inis, or is ther something else I'd have to know?

Nope. Just change the sprite. You might have to change the offset if you do some really freaky stuff with the sprite, but that's it.

Okay, one more thing, Say I made the sprite bigger, would I have to worry about it crushing itself or anything?

nah, because it won't weight anymore just because of your sprite... Or Asplode