The analog sticks on my Xbox360 controller don't seem to pick up on Cortex Command, I picked up the driver for them at: http://tattiebogle.net/index.php/Projec ... /OsxDriver
Everything seems to be good, I've tried it on other games, and it works fine, apart from with CC...

I'm on a Mac, if that helps...

I have this issue too using the mac version of cortex command on steam, using the same driver (version 0.11) on mountain lion (10.8.2). Using an xbox360 controller, I can play other games using the dual stick just fine, but on cortex command the analog sticks won't register at all when trying to set the controls.

Using the preset xbox360 setting under the controller option has the cursor moving up and to the left and still no registering movement of the analog. Any fix or suggestions on this?

I have this same problem as well. I just bought the game a couple hours ago on Steam for OSX, and neither of my two xbox 360 controllers' analog sticks work. I'm using this driver:
http://tattiebogle.net/index.php/Projec ... /OsxDriver

Which has worked great for every other game I've used it with.

I tried playing using just the Dpad but it's not very good that way.

I mainly bought the game to play with friends locally, so I feel like I've wasted my money...

This is a known issue, since February at least. The problem is that either the mac drivers or CC maps the analog axis to the triggers, or something along those lines. There is more information here.

As far as I could find, there's no way to solve this as of yet.

Oh, that's a shame. I really prefer playing games on an xbox controller versus keyboard/mouse, and very detailed writeup of the issue in that link. Hopefully it'll get fixed up.

What's the recommended way to play if without a gamepad? Keyboard + mouse, or just keyboard?

Either works, I personally recommend keyboard and mouse since it gives you greater aim control.

I prefer keyboard+mouse, but Xbox 360 controllers are OK too.

This does seem like it would be a fun game to play with 4 friends on a big TV, but this issue is stopping me from doing that. Very frustrating.